P2Y Receptor Agonist

P2Y Receptor Agonists (22):

Cat. No.	Product Name	Effect	Purity

HY-108661A

NF546 hydrate	Agonist
NF546 (hydrate) is a selective non-nucleotide P2Y11 agonist with a pEC₅₀ of 6.27. NF546 (hydrate) stimulates release of interleukin-8 from human monocyte-derived dendritic cells.

HY-110089

mrs 4062 TFA	Agonist
mrs 4062 (TFA) is a selective P2Y₄ receptor agonist with an EC₅₀ of 23 nM. mrs 4062 (TFA) has EC₅₀s of 640 nM and 740 nM for P2Y₂ and P2Y₆, respectively.

HY-113359AS2

Uridine 5'-diphosphate-¹³C₉,¹⁵N₂ dilithium	Agonist	99.5%
Uridine 5'-diphosphate-¹³C₉,¹⁵N₂ dilithium is ¹³C and ¹⁵N-labeled Uridine 5'-diphosphate (HY-113359). Uridine 5'-diphosphate is a P2Y₆ receptor agonist with an EC₅₀ of 0.013 μM for human P2Y₆ receptor.

HY-108661

NF546	Agonist
NF546 is a selective non-nucleotide P2Y11 agonist with a pEC₅₀ of 6.27. NF546 stimulates release of interleukin-8 from human monocyte-derived dendritic cells.

HY-108651

Uridine-5'-O-(3-thiotriphosphate) trisodium	Agonist
Uridine-5'-O-(3-thiotriphosphate) trisodium, a stable analogue of UTP, is a potent agonist of the P2Y2 and P2Y4 receptors with increased metabolic stability.

HY-134361

ATP-γ-S tetrasodium	Agonist
ATP-γ-S (tetrasodium) is a P2Y11 receptor agonist, an antioxidant and a neuroprotective agent. ATP-γ-S (tetrasodium) can be used as a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A. ATP-γ-S (tetrasodium) is active in ATP hydrolysis.

HY-108664

MRS2957	Agonist
MRS2957 is a P2Y6 receptor agonist that activates AMPK in pancreatic β-cells, promoting insulin secretion and reducing apoptosis, thereby holding potential as a therapeutic target for type 2 diabetes.

HY-137616C

Rp-dUTPαS tetrasodium	Agonist
Rp-dUTPαS (tetrasodium) is an isomer of the sulfur-containing nucleoride dUTP-α-S and an agonist of the purinergic P2Y₂ receptor. Rp-dUTPαS (tetrasodium) selectively induces inositol phosphate accumulation in P2Y₂-expressing 1321N1 cells with an EC₅₀ of 12.5 μM.

HY-113359AS1

Uridine 5'-diphosphate-¹³C₉ dilithium	Agonist
Uridine 5'-diphosphate-¹³C₉ dilithium is ¹³C-labeled Uridine 5'-diphosphate (HY-113359). Uridine 5'-diphosphate is a P2Y₆ receptor agonist with an EC₅₀ of 0.013 μM for human P2Y₆ receptor.

HY-116295A

MRS2690 disodium	Agonist
MRS2690 disodium is a selective P2Y14 receptor agonist. MRS2690 disodium inhibits adenylyl cyclase activity, thereby reducing intracellular cAMP levels and mediating concentration-dependent vasoconstriction of porcine coronary arteries. MRS2690 disodium induces intracellular calcium mobilization, activates P38 and stimulates [³⁵S]GTPγS binding to RBL-2H3 cell membranes. MRS2690 enhances antigen (NP-BSA)-, C3a-induced β-hexosaminidase (β-Hex) release. MRS2690 disodium can be used for ischemic heart disease.

HY-108650

2-Thio-UTP tetrasodium	Agonist
2-Thio-UTP tetrasodium is a potent P2Y₂, P2Y₄ and P2Y₆ agonist, which an be used for the research of cancer.

HY-137612C

Rp-UTP-α-S tetrasodium	Agonist
Rp-UTP-α-S (tetrasodium) is a nucleotide agonist of purinergic P2Y₂ and P2Y₄ receptors. Rp-UTP-α-S (tetrasodium) can induce inositol phosphate accumulation in P2Y₂ or P2Y₄ expressing 1321N1 cells with EC₅₀ values of 5.4 and 27 μM.

HY-108654

PSB 0474	Agonist
PSB 0474 (3-phenacyl-UDP) is a selective and potent P2Y₆ receptor agonist with an EC₅₀ of 70 nM. PSB 0474 inhibits cell proliferation, increases NO release in astrocytes and microglia cells. PSB 0474 induces astrocytes apoptosis.

HY-110092A

PSB-1114 triethylamine	Agonist
PSB-1114 triethylamine is a potent, enzymatically stable, and subtype-selective P2Y₂ receptor agonist with an EC₅₀ of 134 nM. PSB-1114 triethylamine displays >50-fold selectivity versus the P2Y₄ (EC₅₀ of 9.3 μM) and P2Y₆ (EC₅₀ of 7.0 μM) receptors.

HY-113359AS3

Uridine 5'-diphosphate-¹⁵N₂ dilithium	Agonist
Uridine 5'-diphosphate-¹⁵N₂ dilithium is ¹⁵N labeled Uridine 5'-diphosphate (HY-113359). Uridine 5'-diphosphate is a P2Y₆ receptor agonist with an EC₅₀ of 0.013 μM for human P2Y₆ receptor.

HY-110092

PSB-1114 tetrasodium	Agonist
PSB-1114 tetrasodium is a potent, enzymatically stable, and subtype-selective P2Y₂ receptor agonist with an EC₅₀ of 134 nM. PSB-1114 tetrasodium displays >50-fold selectivity versus the P2Y₄ (EC₅₀ of 9.3 μM) and P2Y₆ (EC₅₀ of 7.0 μM) receptors.

HY-137603

Uridine-5'-O-3-thiotriphosphate	Agonist
Uridine-5'-O-(3-thiotriphosphate) (UTPγS), a stable analogue of UTP, is a potent agonist of the P2Y2 and P2Y4 receptors with increased metabolic stability.

HY-116295

MRS2690	Agonist
MRS2690 is a selective P2Y14 receptor agonist. MRS2690 inhibits adenylyl cyclase activity, thereby reducing intracellular cAMP levels and mediating concentration-dependent vasoconstriction of porcine coronary arteries. MRS2690 induces intracellular calcium mobilization, activates P38 and stimulates [³⁵S]GTPγS binding to RBL-2H3 cell membranes. MRS2690 enhances antigen (NP-BSA)-, C3a-induced β-hexosaminidase (β-Hex) release. MRS2690can be used for ischemic heart disease.

HY-117356B

MRS2693 trisodium	Agonist
MRS2693 trisodium is a selective P2Y6 agonist with an EC₅₀ value of 0.015 μM. MRS2693 trisodium can reduce the activation of NF-kappaB and activate the ERK1/2 pathway, and has a cytoprotective effect on mouse hindlimb skeletal muscle ischemia-reperfusion injury model.

HY-137608

Uridine 5'-O-thiodiphosphate	Agonist
Uridine 5'-O-thiodiphosphate (UDP-β-S) is a stable analog of UDP. As a selective agonist of P2Y6 receptor, Uridine 5'-O-thiodiphosphate has higher metabolic stability and can be used in the study of cardiovascular diseases.

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